Systematic Review and Meta-Analysis – JAMA Februari 1, 2024

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Physical activity is associated with the risk for cognitive decline, but much of the evidence in this domain comes from studies with short follow-ups, which is prone to reverse causation bias.

Objective: To examine how length of follow-up, baseline age, physical activity amount, and study quality modify the longitudinal associations of physical activity with cognition.

Paula Iso-Markku, MD, PhD; Sari Aaltonen, PhD; Urho M. Kujala, MD, PhD; Hanna-Leena Halme, PhD; Daniel Phipps, PhD; Keegan Knittle, PhD; Eero Vuoksimaa, PhD; KatjaWaller, PhD

JAMA Network Open. 2024;7(2):e2354285. doi:10.1001/jamanetworkopen.2023.54285

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